If you are running a 32-bit version of the Windows 10 operating system and are trying to install the 64-bit version of an application, you will see this error. Similarly, if you are trying to install a 32-bit application on a 64-bit version of the Windows 10 operating system, you will see the same error. In this case, there really is only one possible solution - you have to find the correct version of the required application and install it. Sometimes, the error message "This application cannot run on your PC" may be false. Therefore, if you have tried the above solutions, but still see this error in front of you, and despite the warning, you still need to run the application, then, as an option, try disabling the SmartScreen filter.